Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications

Donald C. Aduba, Evan D. Margaretta, Alexandra E.C. Marnot, Katherine V. Heifferon, Wyatt R. Surbey, Nicholas A. Chartrain, Abby R. Whittington, Timothy Edward Long, Christopher B. Williams*

*この研究の対応する著者

    研究成果査読

    29 被引用数 (Scopus)

    抄録

    Additive manufacturing (AM) is an emerging processing platform in clinical applications because of its ability to fabricate customized 3D structures for patient-specific needs. Vat photopolymerization additive manufacturing creates high-resolution, complex structures with excellent accuracy to fulfill these demands. However, materials selection for vat photopolymerization is limited. Many materials lack the biocompatibility and stimuli-responsive properties for biomaterial function in physiological environments. In this work, a vat photopolymerization AM process photocured acid-labile crosslinker within a methacrylate terminated poly(ethylene glycol) polymer network to yield biocompatible 3D structures with diverse architectures. At physiological temperature (37 °C), photocrosslinked networks exhibited thermal stability and tunable water sorption with respect to crosslinker amount. Crosslinker amount and geometry were varied to control dissolution in aqueous physiological environments. Acid-cleavable crosslinker amount increased dissolution in acidic (pH ˜1) environments. In neutral (pH ˜7) environments, acid-cleavable crosslinker amount did not increase dissolution to the same extent. Geometry, specifically cube and lattice structures exhibited differences in dissolution due to surface area driven diffusion. Structural by-products after dissolution demonstrated good in vitro cytocompatibility after 72-hours in culture. This class of 3D-printed biomaterials offer potential for drug delivery, tissue engineering scaffolds and wound dressing applications.

    本文言語English
    ページ(範囲)204-211
    ページ数8
    ジャーナルMaterials Today Communications
    19
    DOI
    出版ステータスPublished - 2019 6 1

    ASJC Scopus subject areas

    • 材料科学(全般)
    • 材料力学
    • 材料化学

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