Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: Functional MRI study

Shinichiro Takiguchi, Takashi X. Fujisawa, Sakae Mizushima, Daisuke N. Saito, Yuko Okamoto, Koji Shimada, Michiko Koizumi, Hirokazu Kumazaki, Minyoung Jung, Hirotaka Kosaka, Michio Hiratani, Yusei Ohshima, Martin H. Teicher, Akemi Tomoda*

*この研究の対応する著者

研究成果: Article査読

31 被引用数 (Scopus)

抄録

Background Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD). Aims To examine whether neural activity during reward processing was altered in children and adolescents with RAD. Method Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging. Results Significantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups. Conclusions Striatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology.

本文言語English
ページ(範囲)121-128
ページ数8
ジャーナルBJPsych Open
1
2
DOI
出版ステータスPublished - 2015
外部発表はい

ASJC Scopus subject areas

  • 精神医学および精神衛生

フィンガープリント

「Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: Functional MRI study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル