Violation of the fluctuation-dissipation theorem in a protein system

Kumiko Hayashi*, Mitsunori Takano

*この研究の対応する著者

研究成果: Article査読

22 被引用数 (Scopus)

抄録

We report the results of molecular dynamics simulations of the protein myosin carried out with an elastic network model. Quenching the system, we observe glassy behavior of a density correlation function and a density response function that are often investigated in structure glasses and spin glasses. In the equilibrium, the fluctuation-response relation, a representative relation of the fluctuation-dissipation theorem, holds that the ratio of the density correlation function to the density response function is equal to the temperature of the environment. We show that, in the quenched system that we study, this relation can be violated. In the case that this relation does not hold, this ratio can be regarded as an effective temperature. We find that this effective temperature of myosin is higher than the temperature of the environment. We discuss the relation between this effective temperature and energy transduction that occurs after ATP hydrolysis in the myosin molecule.

本文言語English
ページ(範囲)895-901
ページ数7
ジャーナルBiophysical Journal
93
3
DOI
出版ステータスPublished - 2007 8

ASJC Scopus subject areas

  • 生物理学

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