Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito; Masami Miura; Hidekazu Furuse; Chen Zhixiong; Hiroshi Kato; Daisuke Yasutomi; Takafumi Inoue; Katsuhiko Mikoshiba; Tetsutoshi Kimura; Shunpei Sakakibara; Hiroyoshi Miyakawa

doi:10.1016/0304-3940(94)11127-5

Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito^*, Masami Miura, Hidekazu Furuse, Chen Zhixiong, Hiroshi Kato, Daisuke Yasutomi, Takafumi Inoue, Katsuhiko Mikoshiba, Tetsutoshi Kimura, Shunpei Sakakibara, Hiroyoshi Miyakawa

^*この研究の対応する著者

研究成果: Article › 査読

48 被引用数 (Scopus)

抄録

It is widely believed that a rise in post-synaptic calcium concentration ([Ca²⁺];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca²⁺ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni²⁺, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca²⁺ entry through VGCC is an important step in this form of LTP.

本文言語	English
ページ（範囲）	112-115
ページ数	4
ジャーナル	Neuroscience Letters
巻	183
号	1-2
DOI	https://doi.org/10.1016/0304-3940(94)11127-5
出版ステータス	Published - 1995 1月 2
外部発表	はい

ASJC Scopus subject areas

神経科学（全般）

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10.1016/0304-3940(94)11127-5

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引用スタイル

Ito, K. I., Miura, M., Furuse, H., Zhixiong, C., Kato, H., Yasutomi, D., Inoue, T., Mikoshiba, K., Kimura, T., Sakakibara, S., & Miyakawa, H. (1995). Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. Neuroscience Letters, 183(1-2), 112-115. https://doi.org/10.1016/0304-3940(94)11127-5

Ito, KI, Miura, M, Furuse, H, Zhixiong, C, Kato, H, Yasutomi, D, Inoue, T, Mikoshiba, K, Kimura, T, Sakakibara, S & Miyakawa, H 1995, 'Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons', Neuroscience Letters, vol. 183, no. 1-2, pp. 112-115. https://doi.org/10.1016/0304-3940(94)11127-5

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title = "Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons",

abstract = "It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.",

keywords = "2-Amino-5-phosphonovalerate, Ca channels, Hippocampus, Long-term potentiation, Nickel, ω-AgaIVA",

author = "Ito, {Ken ichi} and Masami Miura and Hidekazu Furuse and Chen Zhixiong and Hiroshi Kato and Daisuke Yasutomi and Takafumi Inoue and Katsuhiko Mikoshiba and Tetsutoshi Kimura and Shunpei Sakakibara and Hiroyoshi Miyakawa",

note = "Funding Information: This work was supported by the Human Frontier Science Program, the Sumitomo Foundation (No. 92-103-247), and the Ministry of Education, Science and Culture(No. 06260206). We thank Dr. W.N. Ross for helpful comments.",

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doi = "10.1016/0304-3940(94)11127-5",

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AU - Ito, Ken ichi

AU - Miura, Masami

AU - Furuse, Hidekazu

AU - Zhixiong, Chen

AU - Kato, Hiroshi

AU - Yasutomi, Daisuke

AU - Inoue, Takafumi

AU - Mikoshiba, Katsuhiko

AU - Kimura, Tetsutoshi

AU - Sakakibara, Shunpei

AU - Miyakawa, Hiroyoshi

N1 - Funding Information: This work was supported by the Human Frontier Science Program, the Sumitomo Foundation (No. 92-103-247), and the Ministry of Education, Science and Culture(No. 06260206). We thank Dr. W.N. Ross for helpful comments.

PY - 1995/1/2

Y1 - 1995/1/2

N2 - It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

AB - It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

KW - 2-Amino-5-phosphonovalerate

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KW - Nickel

KW - ω-AgaIVA

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