Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito*, Masami Miura, Hidekazu Furuse, Chen Zhixiong, Hiroshi Kato, Daisuke Yasutomi, Takafumi Inoue, Katsuhiko Mikoshiba, Tetsutoshi Kimura, Shunpei Sakakibara, Hiroyoshi Miyakawa

*この研究の対応する著者

研究成果: Article査読

47 被引用数 (Scopus)

抄録

It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

本文言語English
ページ(範囲)112-115
ページ数4
ジャーナルNeuroscience Letters
183
1-2
DOI
出版ステータスPublished - 1995 1 2
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Voltage-gated Ca<sup>2+</sup> channel blockers, ω-AgalVA and Ni<sup>2+</sup>, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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