Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito; Masami Miura; Hidekazu Furuse; Chen Zhixiong; Hiroshi Kato; Daisuke Yasutomi; Takafumi Inoue; Katsuhiko Mikoshiba; Tetsutoshi Kimura; Shunpei Sakakibara; Hiroyoshi Miyakawa

doi:10.1016/0304-3940(94)11127-5

Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito, Masami Miura, Hidekazu Furuse, Chen Zhixiong, Hiroshi Kato, Daisuke Yasutomi, Takafumi Inoue, Katsuhiko Mikoshiba, Tetsutoshi Kimura, Shunpei Sakakibara, Hiroyoshi Miyakawa

研究成果: Article › 査読

47 被引用数 (Scopus)

抄録

It is widely believed that a rise in post-synaptic calcium concentration ([Ca²⁺];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca²⁺ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni²⁺, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca²⁺ entry through VGCC is an important step in this form of LTP.

本文言語	English
ページ（範囲）	112-115
ページ数	4
ジャーナル	Neuroscience Letters
巻	183
号	1-2
DOI	https://doi.org/10.1016/0304-3940(94)11127-5
出版ステータス	Published - 1995 1 2
外部発表	はい

ASJC Scopus subject areas

Neuroscience(all)

文献へのアクセス

10.1016/0304-3940(94)11127-5

他のファイルとリンク

フィンガープリント「Voltage-gated Ca<sup>2+</sup> channel blockers, ω-AgalVA and Ni<sup>2+</sup>, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Ito, K. I., Miura, M., Furuse, H., Zhixiong, C., Kato, H., Yasutomi, D., Inoue, T., Mikoshiba, K., Kimura, T., Sakakibara, S., & Miyakawa, H. (1995). Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. Neuroscience Letters, 183(1-2), 112-115. https://doi.org/10.1016/0304-3940(94)11127-5

Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. / Ito, Ken ichi; Miura, Masami; Furuse, Hidekazu; Zhixiong, Chen; Kato, Hiroshi; Yasutomi, Daisuke; Inoue, Takafumi; Mikoshiba, Katsuhiko; Kimura, Tetsutoshi; Sakakibara, Shunpei; Miyakawa, Hiroyoshi.

In: Neuroscience Letters, Vol. 183, No. 1-2, 02.01.1995, p. 112-115.

研究成果: Article › 査読

Ito, KI, Miura, M, Furuse, H, Zhixiong, C, Kato, H, Yasutomi, D, Inoue, T, Mikoshiba, K, Kimura, T, Sakakibara, S & Miyakawa, H 1995, 'Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons', Neuroscience Letters, vol. 183, no. 1-2, pp. 112-115. https://doi.org/10.1016/0304-3940(94)11127-5

Ito, Ken ichi ; Miura, Masami ; Furuse, Hidekazu ; Zhixiong, Chen ; Kato, Hiroshi ; Yasutomi, Daisuke ; Inoue, Takafumi ; Mikoshiba, Katsuhiko ; Kimura, Tetsutoshi ; Sakakibara, Shunpei ; Miyakawa, Hiroyoshi. / Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. In: Neuroscience Letters. 1995 ; Vol. 183, No. 1-2. pp. 112-115.

@article{29a269a1a3bc4f1884b4fe09dbc013dd,

title = "Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons",

abstract = "It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.",

keywords = "2-Amino-5-phosphonovalerate, Ca channels, Hippocampus, Long-term potentiation, Nickel, ω-AgaIVA",

author = "Ito, {Ken ichi} and Masami Miura and Hidekazu Furuse and Chen Zhixiong and Hiroshi Kato and Daisuke Yasutomi and Takafumi Inoue and Katsuhiko Mikoshiba and Tetsutoshi Kimura and Shunpei Sakakibara and Hiroyoshi Miyakawa",

note = "Funding Information: This work was supported by the Human Frontier Science Program, the Sumitomo Foundation (No. 92-103-247), and the Ministry of Education, Science and Culture(No. 06260206). We thank Dr. W.N. Ross for helpful comments.",

year = "1995",

month = jan,

day = "2",

doi = "10.1016/0304-3940(94)11127-5",

language = "English",

volume = "183",

pages = "112--115",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

AU - Ito, Ken ichi

AU - Miura, Masami

AU - Furuse, Hidekazu

AU - Zhixiong, Chen

AU - Kato, Hiroshi

AU - Yasutomi, Daisuke

AU - Inoue, Takafumi

AU - Mikoshiba, Katsuhiko

AU - Kimura, Tetsutoshi

AU - Sakakibara, Shunpei

AU - Miyakawa, Hiroyoshi

N1 - Funding Information: This work was supported by the Human Frontier Science Program, the Sumitomo Foundation (No. 92-103-247), and the Ministry of Education, Science and Culture(No. 06260206). We thank Dr. W.N. Ross for helpful comments.

PY - 1995/1/2

Y1 - 1995/1/2

N2 - It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

AB - It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

KW - 2-Amino-5-phosphonovalerate

KW - Ca channels

KW - Hippocampus

KW - Long-term potentiation

KW - Nickel

KW - ω-AgaIVA

UR - http://www.scopus.com/inward/record.url?scp=0028981274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028981274&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(94)11127-5

DO - 10.1016/0304-3940(94)11127-5

M3 - Article

C2 - 7746467

AN - SCOPUS:0028981274

VL - 183

SP - 112

EP - 115

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -