Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito; Masami Miura; Hidekazu Furuse; Chen Zhixiong; Hiroshi Kato; Daisuke Yasutomi; Takafumi Inoue; Katsuhiko Mikoshiba; Tetsutoshi Kimura; Shunpei Sakakibara; Hiroyoshi Miyakawa

doi:10.1016/0304-3940(94)11127-5

Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito, Masami Miura, Hidekazu Furuse, Chen Zhixiong, Hiroshi Kato, Daisuke Yasutomi, Takafumi Inoue, Katsuhiko Mikoshiba, Tetsutoshi Kimura, Shunpei Sakakibara, Hiroyoshi Miyakawa

研究成果: Article › 査読

47 被引用数 (Scopus)

抄録

It is widely believed that a rise in post-synaptic calcium concentration ([Ca²⁺];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca²⁺ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni²⁺, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca²⁺ entry through VGCC is an important step in this form of LTP.

本文言語	English
ページ（範囲）	112-115
ページ数	4
ジャーナル	Neuroscience Letters
巻	183
号	1-2
DOI	https://doi.org/10.1016/0304-3940(94)11127-5
出版ステータス	Published - 1995 1 2
外部発表	はい

ASJC Scopus subject areas

Neuroscience(all)

文献へのアクセス

10.1016/0304-3940(94)11127-5

フィンガープリント「Voltage-gated Ca<sup>2+</sup> channel blockers, ω-AgalVA and Ni<sup>2+</sup>, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Ito, K. I., Miura, M., Furuse, H., Zhixiong, C., Kato, H., Yasutomi, D., Inoue, T., Mikoshiba, K., Kimura, T., Sakakibara, S., & Miyakawa, H. (1995). Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. Neuroscience Letters, 183(1-2), 112-115. https://doi.org/10.1016/0304-3940(94)11127-5

Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. / Ito, Ken ichi; Miura, Masami; Furuse, Hidekazu; Zhixiong, Chen; Kato, Hiroshi; Yasutomi, Daisuke; Inoue, Takafumi; Mikoshiba, Katsuhiko; Kimura, Tetsutoshi; Sakakibara, Shunpei; Miyakawa, Hiroyoshi.

In: Neuroscience Letters, Vol. 183, No. 1-2, 02.01.1995, p. 112-115.

研究成果: Article › 査読

Ito, KI, Miura, M, Furuse, H, Zhixiong, C, Kato, H, Yasutomi, D, Inoue, T, Mikoshiba, K, Kimura, T, Sakakibara, S & Miyakawa, H 1995, 'Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons', Neuroscience Letters, vol. 183, no. 1-2, pp. 112-115. https://doi.org/10.1016/0304-3940(94)11127-5

Ito, Ken ichi ; Miura, Masami ; Furuse, Hidekazu ; Zhixiong, Chen ; Kato, Hiroshi ; Yasutomi, Daisuke ; Inoue, Takafumi ; Mikoshiba, Katsuhiko ; Kimura, Tetsutoshi ; Sakakibara, Shunpei ; Miyakawa, Hiroyoshi. / Voltage-gated Ca²⁺ channel blockers, ω-AgalVA and Ni²⁺, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. In: Neuroscience Letters. 1995 ; Vol. 183, No. 1-2. pp. 112-115.

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AU - Inoue, Takafumi

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