TY - JOUR
T1 - Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons
AU - Ito, Ken ichi
AU - Miura, Masami
AU - Furuse, Hidekazu
AU - Zhixiong, Chen
AU - Kato, Hiroshi
AU - Yasutomi, Daisuke
AU - Inoue, Takafumi
AU - Mikoshiba, Katsuhiko
AU - Kimura, Tetsutoshi
AU - Sakakibara, Shunpei
AU - Miyakawa, Hiroyoshi
N1 - Funding Information:
This work was supported by the Human Frontier Science Program, the Sumitomo Foundation (No. 92-103-247), and the Ministry of Education, Science and Culture(No. 06260206). We thank Dr. W.N. Ross for helpful comments.
PY - 1995/1/2
Y1 - 1995/1/2
N2 - It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.
AB - It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.
KW - 2-Amino-5-phosphonovalerate
KW - Ca channels
KW - Hippocampus
KW - Long-term potentiation
KW - Nickel
KW - ω-AgaIVA
UR - http://www.scopus.com/inward/record.url?scp=0028981274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028981274&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)11127-5
DO - 10.1016/0304-3940(94)11127-5
M3 - Article
C2 - 7746467
AN - SCOPUS:0028981274
VL - 183
SP - 112
EP - 115
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -