VPA alleviates neurological deficits and restores gene expression in a mouse model of rett syndrome

Weixiang Guo, Keita Tsujimura, Maky Otsuka I, Koichiro Irie, Katsuhide Igarashi, Kinichi Nakashima, Xinyu Zhao

研究成果: Article

8 引用 (Scopus)

抄録

Rett syndrome (RTT) is a devastating neurodevelopmental disorder that occurs once in every 10,000-15,000 live female births. Despite intensive research, no effective cure is yet available. Valproic acid (VPA) has been used widely to treat mood disorder, epilepsy, and a growing number of other disorders. In limited clinical studies, VPA has also been used to control seizure in RTT patients with promising albeit somewhat unclear efficacy. In this study we tested the effect of VPA on the neurological symptoms of RTT and discovered that short-term VPA treatment during the symptomatic period could reduce neurological symptoms in RTT mice. We found that VPA restores the expression of a subset of genes in RTT mouse brains, and these genes clustered in neurological disease and developmental disorder networks. Our data suggest that VPA could be used as a drug to alleviate RTT symptoms.

元の言語English
記事番号e100215
ジャーナルPLoS One
9
発行部数6
DOI
出版物ステータスPublished - 2014 6 26
外部発表Yes

Fingerprint

valproic acid
Rett Syndrome
Valproic Acid
Gene expression
animal models
Gene Expression
gene expression
signs and symptoms (animals and humans)
Genes
epilepsy
mice
Live Birth
emotions
seizures
acid treatment
Mood Disorders
clinical trials
Epilepsy
Brain
Seizures

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

これを引用

VPA alleviates neurological deficits and restores gene expression in a mouse model of rett syndrome. / Guo, Weixiang; Tsujimura, Keita; Otsuka I, Maky; Irie, Koichiro; Igarashi, Katsuhide; Nakashima, Kinichi; Zhao, Xinyu.

:: PLoS One, 巻 9, 番号 6, e100215, 26.06.2014.

研究成果: Article

Guo, W, Tsujimura, K, Otsuka I, M, Irie, K, Igarashi, K, Nakashima, K & Zhao, X 2014, 'VPA alleviates neurological deficits and restores gene expression in a mouse model of rett syndrome', PLoS One, 巻. 9, 番号 6, e100215. https://doi.org/10.1371/journal.pone.0100215
Guo, Weixiang ; Tsujimura, Keita ; Otsuka I, Maky ; Irie, Koichiro ; Igarashi, Katsuhide ; Nakashima, Kinichi ; Zhao, Xinyu. / VPA alleviates neurological deficits and restores gene expression in a mouse model of rett syndrome. :: PLoS One. 2014 ; 巻 9, 番号 6.
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