Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress

Shuichi Ueda, Shinichi Sakakibara, Eriko Watanabe, Kanji Yoshimoto, Noriyuki Koibuchi

研究成果: Article

12 引用 (Scopus)

抄録

In the monograph of Santiago Ramon y Cajal, he provided a detailed description about the morphological changes in degeneration and regeneration of peripheral and central nervous systems following lesions. He discussed factors that may promote or inhibit axonal growth after peripheral and/or central nerve injury. Cajal with a brilliant insight anticipated the existence of several factors acting on degeneration and regeneration. Free radicals have been proposed to be one of such factors. These highly reactive oxygen species-derived free radicals play a pathogenetic role in neurological disorders, including ischemia, trauma, Alzheimer's disease and Parkinson's disease (PD). In this review we will discuss the similarities and differences between the morphological changes under oxidant stress and Cajal's drawings of degeneration and regeneration following the central injury. The monoaminergic neuron systems in the brainstem appear vulnerable to these free radicals, which have also been implicated in the selective degeneration of the nigrostriatal DA system. We analyzed the degeneration of fibers and the neuronal cell death of brainstem monoaminergic neuron systems in a mutant rat, which has abnormal metabolism of oxygen species in the brain. The degeneration of DA cell bodies and fibers was characterized by swollen varicosities and clustered fibers.

元の言語English
ページ(範囲)293-302
ページ数10
ジャーナルProgress in Brain Research
136
DOI
出版物ステータスPublished - 2002
外部発表Yes

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Brain Stem
Free Radicals
Regeneration
Oxidative Stress
Neurons
Wounds and Injuries
Peripheral Nervous System
Nervous System Diseases
Oxidants
Parkinson Disease
Reactive Oxygen Species
Alzheimer Disease
Cell Death
Ischemia
Central Nervous System
Oxygen
Brain
Growth
Cell Body

ASJC Scopus subject areas

  • Neuroscience(all)

これを引用

Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress. / Ueda, Shuichi; Sakakibara, Shinichi; Watanabe, Eriko; Yoshimoto, Kanji; Koibuchi, Noriyuki.

:: Progress in Brain Research, 巻 136, 2002, p. 293-302.

研究成果: Article

Ueda, Shuichi ; Sakakibara, Shinichi ; Watanabe, Eriko ; Yoshimoto, Kanji ; Koibuchi, Noriyuki. / Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress. :: Progress in Brain Research. 2002 ; 巻 136. pp. 293-302.
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