Walking nanothermometers: Spatiotemporal temperature measurement of transported acidic organelles in single living cells

Kotaro Oyama, Masao Takabayashi, Yoshiaki Takei, Satoshi Arai, Shinji Takeoka, Shin'Ichi Ishiwata, Madoka Suzuki

研究成果: Article査読

57 被引用数 (Scopus)

抄録

We fabricated fluorescent nanoparticles which monitor temperature changes without sensitivity to pH (4-10) and ionic strength (0-500 mM). The nanothermometers spontaneously enter living HeLa cells via endocytosis, enclosed in acidic organelles, i.e., endosome/lysosome, and then transported along microtubules in a temperature-dependent manner, working as "walking nanothermometers".

本文言語English
ページ(範囲)1591-1593
ページ数3
ジャーナルLab on a Chip
12
9
DOI
出版ステータスPublished - 2012 5 7

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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