Water-dispersible cationic polyurethanes containing pendant trialkylphosphoniums

Musan Zhang, Sean T. Hemp, Mingqiang Zhang, Michael H. Allen, Richard N. Carmean, Robert B. Moore, Timothy Edward Long*

*この研究の対応する著者

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Novel trialkylphosphonium ionic liquids chain extenders enabled the successful synthesis of poly(ethylene glycol)-based, cationic polyurethanes with pendant phosphoniums in the hard segments (HS). Aqueous size exclusion chromatography (SEC) confirmed the charged polyurethanes, which varied the phosphonium alkyl substituent length (ethyl and butyl) and cationic HS content (25, 50, 75 mol%), achieved high absolute molecular weights. Dynamic mechanical analysis (DMA) demonstrated the triethylphosphonium (TEP) and tributylphosphonium (TBP) polyurethanes displayed similar thermomechanical properties, including increased rubbery plateau moduli and flow temperatures. Fourier transform infrared spectroscopy (FTIR) emphasized the significance of ion-dipole interaction on hydrogen bonding. Atomic force microscopy (AFM), small-angle X-ray scattering (SAXS), and wide-angle X-ray diffraction (WAXD) supported microphase separated morphologies in the trialkylphosphonium polyurethanes, despite the presence of ionic interactions. Sorption isotherm experiments revealed the TEP polyurethane exhibited the highest water vapor sorption profile compared to the TBP, which displayed similar water sorption profiles to the noncharged analogue. The phosphonium polyurethanes displayed significantly improved tensile strain; however, lower tensile stress of the TEP polyurethane was presumably due to absorbed water. In addition to physical characterizations, we also explored the trialkylphosphonium polyurethanes as nucleic acid delivery vectors. The phosphonium polyurethanes bound DNA at low charge ratios, and the polyplexes exhibited enhanced colloidal stability under physiological salt conditions.

本文言語English
ページ(範囲)3795-3803
ページ数9
ジャーナルPolymer Chemistry
5
12
DOI
出版ステータスPublished - 2014 6月 21
外部発表はい

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生化学
  • 生体医工学
  • ポリマーおよびプラスチック
  • 有機化学

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