What are the elements of motivation for acquisition of conditioned taste aversion?

Koichi Mita, Akiko Okuta, Ryuichi Okada, Dai Hatakeyama, Emi Otsuka, Miki Yamagishi, Mika Morikawa, Yuki Naganuma, Yutaka Fujito, Varvara Dyakonova, Ken Lukowiak, Etsuro Ito

研究成果: Article

18 引用 (Scopus)

抄録

The pond snail Lymnaea stagnalis is capable of being classically conditioned to avoid food and to consolidate this aversion into a long-term memory (LTM). Previous studies have shown that the length of food deprivation is important for both the acquisition of taste aversion and its consolidation into LTM, which is referred to as conditioned taste aversion (CTA). Here we tested the hypothesis that the hemolymph glucose concentration is an important factor in the learning and memory of CTA. One-day food deprivation resulted in the best learning and memory, whereas more prolonged food deprivation had diminishing effects. Five-day food deprivation resulted in snails incapable of learning or remembering. During this food deprivation period, the hemolymph glucose concentration decreased. If snails were fed for 2. days following the 5-day food deprivation, their glucose levels increased significantly and they exhibited both learning and memory, but neither learning nor memory was as good as with the 1-day food-deprived snails. Injection of the snails with insulin to reduce glucose levels resulted in better learning and memory. Insulin is also known to cause a long-term enhancement of synaptic transmission between the feeding-related neurons. On the other hand, injection of glucose into 5-day food-deprived snails did not alter their inability to learn and remember. However, if these snails were fed on sucrose for 3. min, they then exhibited learning and memory formation. Our data suggest that hemolymph glucose concentration is an important factor in motivating acquisition of CTA in Lymnaea and that the action of insulin in the brain and the feeding behavior are also important factors.

元の言語English
ページ(範囲)1-12
ページ数12
ジャーナルNeurobiology of Learning and Memory
107
DOI
出版物ステータスPublished - 2014
外部発表Yes

Fingerprint

Snails
Food Deprivation
Motivation
Learning
Glucose
Hemolymph
Lymnaea
Long-Term Memory
Insulin
Food
Injections
Feeding Behavior
Synaptic Transmission
Sucrose
Neurons
Brain

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

これを引用

What are the elements of motivation for acquisition of conditioned taste aversion? / Mita, Koichi; Okuta, Akiko; Okada, Ryuichi; Hatakeyama, Dai; Otsuka, Emi; Yamagishi, Miki; Morikawa, Mika; Naganuma, Yuki; Fujito, Yutaka; Dyakonova, Varvara; Lukowiak, Ken; Ito, Etsuro.

:: Neurobiology of Learning and Memory, 巻 107, 2014, p. 1-12.

研究成果: Article

Mita, K, Okuta, A, Okada, R, Hatakeyama, D, Otsuka, E, Yamagishi, M, Morikawa, M, Naganuma, Y, Fujito, Y, Dyakonova, V, Lukowiak, K & Ito, E 2014, 'What are the elements of motivation for acquisition of conditioned taste aversion?', Neurobiology of Learning and Memory, 巻. 107, pp. 1-12. https://doi.org/10.1016/j.nlm.2013.10.013
Mita, Koichi ; Okuta, Akiko ; Okada, Ryuichi ; Hatakeyama, Dai ; Otsuka, Emi ; Yamagishi, Miki ; Morikawa, Mika ; Naganuma, Yuki ; Fujito, Yutaka ; Dyakonova, Varvara ; Lukowiak, Ken ; Ito, Etsuro. / What are the elements of motivation for acquisition of conditioned taste aversion?. :: Neurobiology of Learning and Memory. 2014 ; 巻 107. pp. 1-12.
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abstract = "The pond snail Lymnaea stagnalis is capable of being classically conditioned to avoid food and to consolidate this aversion into a long-term memory (LTM). Previous studies have shown that the length of food deprivation is important for both the acquisition of taste aversion and its consolidation into LTM, which is referred to as conditioned taste aversion (CTA). Here we tested the hypothesis that the hemolymph glucose concentration is an important factor in the learning and memory of CTA. One-day food deprivation resulted in the best learning and memory, whereas more prolonged food deprivation had diminishing effects. Five-day food deprivation resulted in snails incapable of learning or remembering. During this food deprivation period, the hemolymph glucose concentration decreased. If snails were fed for 2. days following the 5-day food deprivation, their glucose levels increased significantly and they exhibited both learning and memory, but neither learning nor memory was as good as with the 1-day food-deprived snails. Injection of the snails with insulin to reduce glucose levels resulted in better learning and memory. Insulin is also known to cause a long-term enhancement of synaptic transmission between the feeding-related neurons. On the other hand, injection of glucose into 5-day food-deprived snails did not alter their inability to learn and remember. However, if these snails were fed on sucrose for 3. min, they then exhibited learning and memory formation. Our data suggest that hemolymph glucose concentration is an important factor in motivating acquisition of CTA in Lymnaea and that the action of insulin in the brain and the feeding behavior are also important factors.",
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AU - Mita, Koichi

AU - Okuta, Akiko

AU - Okada, Ryuichi

AU - Hatakeyama, Dai

AU - Otsuka, Emi

AU - Yamagishi, Miki

AU - Morikawa, Mika

AU - Naganuma, Yuki

AU - Fujito, Yutaka

AU - Dyakonova, Varvara

AU - Lukowiak, Ken

AU - Ito, Etsuro

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KW - Lymnaea

KW - Motivation

KW - Sucrose

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