YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008

Fumito Koizumi, Naomi Fukumitsu, Jinrong Zhao, Ruthada Chanklan, Tokichi Miyakawa, Shoko Kawahara, Shin Iwamoto, Makoto Suzuki, Shingo Kakita, Endang S. Rahayu, Seijiro Hosokawa, Kuniaki Tatsuta, Michio Ichimura

    研究成果: Article

    24 引用 (Scopus)

    抄録

    In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.

    元の言語English
    ページ(範囲)455-458
    ページ数4
    ジャーナルJournal of Antibiotics
    60
    発行部数7
    DOI
    出版物ステータスPublished - 2007 7

    Fingerprint

    Fusarium
    Preclinical Drug Evaluations
    Growth
    Fermentation
    Saccharomyces cerevisiae
    Chromatography
    Yeasts
    High Pressure Liquid Chromatography
    YCM 1008A

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery
    • Molecular Medicine

    これを引用

    Koizumi, F., Fukumitsu, N., Zhao, J., Chanklan, R., Miyakawa, T., Kawahara, S., ... Ichimura, M. (2007). YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. Journal of Antibiotics, 60(7), 455-458. https://doi.org/10.1038/ja.2007.58

    YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. / Koizumi, Fumito; Fukumitsu, Naomi; Zhao, Jinrong; Chanklan, Ruthada; Miyakawa, Tokichi; Kawahara, Shoko; Iwamoto, Shin; Suzuki, Makoto; Kakita, Shingo; Rahayu, Endang S.; Hosokawa, Seijiro; Tatsuta, Kuniaki; Ichimura, Michio.

    :: Journal of Antibiotics, 巻 60, 番号 7, 07.2007, p. 455-458.

    研究成果: Article

    Koizumi, F, Fukumitsu, N, Zhao, J, Chanklan, R, Miyakawa, T, Kawahara, S, Iwamoto, S, Suzuki, M, Kakita, S, Rahayu, ES, Hosokawa, S, Tatsuta, K & Ichimura, M 2007, 'YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008', Journal of Antibiotics, 巻. 60, 番号 7, pp. 455-458. https://doi.org/10.1038/ja.2007.58
    Koizumi F, Fukumitsu N, Zhao J, Chanklan R, Miyakawa T, Kawahara S その他. YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. Journal of Antibiotics. 2007 7;60(7):455-458. https://doi.org/10.1038/ja.2007.58
    Koizumi, Fumito ; Fukumitsu, Naomi ; Zhao, Jinrong ; Chanklan, Ruthada ; Miyakawa, Tokichi ; Kawahara, Shoko ; Iwamoto, Shin ; Suzuki, Makoto ; Kakita, Shingo ; Rahayu, Endang S. ; Hosokawa, Seijiro ; Tatsuta, Kuniaki ; Ichimura, Michio. / YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. :: Journal of Antibiotics. 2007 ; 巻 60, 番号 7. pp. 455-458.
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    abstract = "In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.",
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    AU - Zhao, Jinrong

    AU - Chanklan, Ruthada

    AU - Miyakawa, Tokichi

    AU - Kawahara, Shoko

    AU - Iwamoto, Shin

    AU - Suzuki, Makoto

    AU - Kakita, Shingo

    AU - Rahayu, Endang S.

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