YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008

Fumito Koizumi, Naomi Fukumitsu, Jinrong Zhao, Ruthada Chanklan, Tokichi Miyakawa, Shoko Kawahara, Shin Iwamoto, Makoto Suzuki, Shingo Kakita, Endang S. Rahayu, Seijiro Hosokawa, Kuniaki Tatsuta, Michio Ichimura

研究成果: Article査読

28 被引用数 (Scopus)

抄録

In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.

本文言語English
ページ(範囲)455-458
ページ数4
ジャーナルJournal of Antibiotics
60
7
DOI
出版ステータスPublished - 2007 7

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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