YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008

Fumito Koizumi, Naomi Fukumitsu, Jinrong Zhao, Ruthada Chanklan, Tokichi Miyakawa, Shoko Kawahara, Shin Iwamoto, Makoto Suzuki, Shingo Kakita, Endang S. Rahayu, Seijiro Hosokawa, Kuniaki Tatsuta, Michio Ichimura

研究成果: Article

25 引用 (Scopus)


In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.

ジャーナルJournal of Antibiotics
出版物ステータスPublished - 2007 7 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

フィンガープリント YCM1008A, a novel Ca<sup>2+</sup>-signaling inhibitor, produced by Fusarium sp. YCM1008' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Koizumi, F., Fukumitsu, N., Zhao, J., Chanklan, R., Miyakawa, T., Kawahara, S., Iwamoto, S., Suzuki, M., Kakita, S., Rahayu, E. S., Hosokawa, S., Tatsuta, K., & Ichimura, M. (2007). YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. Journal of Antibiotics, 60(7), 455-458. https://doi.org/10.1038/ja.2007.58