yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family

K. Semba; M. Nishizawa; N. Miyajima; M. C. Yoshida; J. Sukegawa; Y. Yamanashi; M. Sasaki; T. Yamamoto; K. Toyoshima

doi:10.1073/pnas.83.15.5459

yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family

K. Semba, M. Nishizawa, N. Miyajima, M. C. Yoshida, J. Sukegawa, Y. Yamanashi, M. Sasaki, T. Yamamoto, K. Toyoshima

先進理工学部

研究成果: Article

130 引用（Scopus）

抜粋

An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.

元の言語	English
ページ（範囲）	5459-5463
ページ数	5
ジャーナル	Proceedings of the National Academy of Sciences of the United States of America
巻	83
発行部数	15
DOI	https://doi.org/10.1073/pnas.83.15.5459
出版物ステータス	Published - 1986 12 19

フィンガープリント

ASJC Scopus subject areas

General

これを引用

Semba, K., Nishizawa, M., Miyajima, N., Yoshida, M. C., Sukegawa, J., Yamanashi, Y., Sasaki, M., Yamamoto, T., & Toyoshima, K. (1986). yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proceedings of the National Academy of Sciences of the United States of America, 83(15), 5459-5463. https://doi.org/10.1073/pnas.83.15.5459

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abstract = "An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.",

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T1 - yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family

AU - Semba, K.

AU - Nishizawa, M.

AU - Miyajima, N.

AU - Yoshida, M. C.

AU - Sukegawa, J.

AU - Yamanashi, Y.

AU - Sasaki, M.

AU - Yamamoto, T.

AU - Toyoshima, K.

PY - 1986/12/19

Y1 - 1986/12/19

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AB - An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.

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文献にアクセス

10.1073/pnas.83.15.5459