YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions

Eri Ikeda*, Satoshi Yoshida, Hiroshi Mitsuzawa, Isao Uno, Akio Toh-e

*この研究の対応する著者

研究成果: Article査読

69 被引用数 (Scopus)

抄録

The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E coli, indicating that YGE1 is a functional homologue of grpE. Deletion of YGE1 is lethal. During depletion of the Ygel product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Ygel protein plays a pivotal role in maintaining mitochondrial functions.

本文言語English
ページ(範囲)265-268
ページ数4
ジャーナルFEBS Letters
339
3
DOI
出版ステータスPublished - 1994 2 21
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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