YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Kai Yamamoto, Yushi Futamura, Rachael A. Uson-Lopez, Harumi Aono, Takeshi Shimizu, Hiroyuki Osada*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A new antifungal compound YO-001A was found from the culture broth of Streptomyces sp. YO15-A001, which was isolated from a soil sample collected in Toyama Prefecture. YO-001A was identified through morphological changes-based screening of the rice blast fungus, Pyricularia oryzae (P. oryzae). YO-001A is a new 26-membered macrolide of the oligomycin family, which exhibits potent antifungal activity against P. oryzae with an IC50 of 0.012 µM by disrupting mitochondrial respiration via inhibition of the FOF1-ATPase activity.

本文言語English
ページ(範囲)986-990
ページ数5
ジャーナルJournal of Antibiotics
72
12
DOI
出版ステータスPublished - 2019 12月 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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